The Wang lab is interested in understanding the molecular basis of host immune modulation mediated by Toxoplasma secreted effectors, and in elucidating the innate immune machinery determining Toxoplasma susceptibility between different hosts. Activation of such anti-Toxoplasma machinery or inhibition of the immunomodulatory parasite effectors could sensitize the parasite to immune surveillance and lead to a better treatment against Toxoplasma infection in immunocompromised patients. To achieve the goals, we apply a multifaceted approach, including functional genomics, proteomics, molecular biology techniques, bioinformatics, and other biochemical analysis.