Publications

Peer-reviewed Publications

2024

• Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. mBio. 2024 Feb 20;:e0330223. doi: 10.1128/mbio.03302-23. PubMed PMID: 38376248.

2023

• Paredes-Santos TC, Bitew MA, Swale C, Rodriguez F, Krishnamurthy S, Wang Y, Maru P, Sangaré LO, Saeij JPJ. Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma. PLoS Pathog. 2023 Jul 27;19(7):e1011543. doi: 10.1371/journal.ppat.1011543. PubMed PMID: 37498952.

• Wang Y. mSphere of Influence: Systemic decoding gene function in Toxoplasma gondii pathogenesis-CRISPR screens and beyond. mSphere. 2023 Jun 29;:e0027123. doi: 10.1128/msphere.00271-23. PubMed PMID: 37382434.

• Krishnamurthy S, Maru P, Wang Y, Bitew MA, Mukhopadhyay D, Yamaryo-Botté Y, Paredes-Santos TC, Sangaré LO, Swale C, Botté CY, Saeij JPJ. CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells. mBio. 2023 Apr 25;14(2):e0006023. doi: 10.1128/mbio.00060-23. Epub 2023 Mar 14. PubMed PMID: 36916910.

2021

• Sangaré LO, Wang Y, Arranz-Solís D, Saeij JPJ. CRISPR screen to determine the in vivo fitness of Toxoplasma genes. STAR Protoc. 2021 Jun 18;2(2):100520. doi: 10.1016/j.xpro.2021.100520. eCollection 2021 Jun 18. PubMed PMID: 34013213.

2020

• Wang Y*, Sangaré LO*, Paredes-Santos TC, Hassan MA, Krishnamurthy S, Furuta AM, Markus BM, Lourido S, Saeij JPJ. Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages. Nat Commun. 2020 Oct 16;11(1):5258. doi: 10.1038/s41467-020-18991-8. PubMed PMID: 33067458. *Co-first authors

• Wang Y*, Sangaré LO*, Paredes-Santos TC, Saeij JPJ. Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface. Annu Rev Microbiol. 2020 Sep 8;74:567-586. doi: 10.1146/annurev-micro-011720-122318. Epub 2020 Jul 17. Review. PubMed PMID: 32680452. *Co-first authors

2019

• Sangaré LO, Ólafsson EB, Wang Y, Yang N, Julien L, Camejo A, Pesavento P, Sidik SM, Lourido S, Barragan A, Saeij JPJ. In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration. Cell Host Microbe. 2019 Oct 9;26(4):478-492.e8. doi: 10.1016/j.chom.2019.09.008. PubMed PMID: 31600500. Recommendations in Faculty Opinions.

• Paredes-Santos T, Wang Y, Waldman B, Lourido S, Saeij JP. The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability. Front Cell Infect Microbiol. 2019;9:321. doi: 10.3389/fcimb.2019.00321. eCollection 2019. PubMed PMID: 31572690.

• Wang Y*, Cirelli KM*, Barros PDC, Sangaré LO, Butty V, Hassan MA, Pesavento P, Mete A, Saeij JPJ. Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis. mBio. 2019 Jan 8;10(1). doi: 10.1128/mBio.02388-18. PubMed PMID: 30622189. *Co-first authors

2017

• Pan M, Zhou Y, Wang Y, Li L, Song Y, Hou L, Zhao J. Screening and Identification of the Host Proteins Interacting with Toxoplasma gondii Rhoptry Protein ROP16. Front Microbiol. 2017;8:2408. doi: 10.3389/fmicb.2017.02408. eCollection 2017. PubMed PMID: 29255456.

2016

• Shen B, Yuan Y, Cheng J, Pan M, Xia N, Zhang W, Wang Y, Zhou Y, Zhao J. Activation of chronic toxoplasmosis by transportation stress in a mouse model. Oncotarget. 2016 Dec 27;7(52):87351-87360. doi: 10.18632/oncotarget.13568. PubMed PMID: 27895319.

• Wang Y, Fang R, Yuan Y, Pan M, Hu M, Zhou Y, Shen B, Zhao J. Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3. Parasitol Res. 2016 Jul;115(7):2825-35. doi: 10.1007/s00436-016-5033-2. Epub 2016 Apr 6. PubMed PMID: 27053129.

2014

• Wang Y, Fang R, Yuan Y, Hu M, Zhou Y, Zhao J. Identification of host proteins interacting with the integrin-like A domain of Toxoplasma gondii micronemal protein MIC2 by yeast-two-hybrid screening. Parasit Vectors. 2014 Nov 26;7:543. doi: 10.1186/s13071-014-0543-1. PubMed PMID: 25423901.

• Li FC, Gasser RB, Lok JB, Korhonen PK, Wang YF, Yin FY, He L, Zhou R, Zhao JL, Hu M. Exploring the role of two interacting phosphoinositide 3-kinases of Haemonchus contortus. Parasit Vectors. 2014 Nov 12;7:498. doi: 10.1186/s13071-014-0498-2. PubMed PMID: 25388625.

• Tao Q, Xiao J, Wang Y, Fang K, Li N, Hu M, Zhou Y, Zhao J. Identification of genes expressed during Toxoplasma gondii infection by in vivo-induced antigen technology (IVIAT) with positive porcine sera. J Parasitol. 2014 Aug;100(4):470-9. doi: 10.1645/13-240.1. Epub 2014 Mar 19. PubMed PMID: 24646180.

• Khan MK, He L, Zhang W, Wang Y, Tao Q, Song Q, Sajid MS, Yu Q, Hu J, Fang R, Hu M, Zhou Y, Zhao J. Identification of two novel HSP90 proteins in Babesia orientalis: molecular characterization, and computational analyses of their structure, function, antigenicity and inhibitor interaction. Parasit Vectors. 2014 Jun 26;7:293. doi: 10.1186/1756-3305-7-293. PubMed PMID: 24970594.

2013

• Tao Q, Fang R, Zhang W, Wang Y, Cheng J, Li Y, Fang K, Khan MK, Hu M, Zhou Y, Zhao J. Protective immunity induced by a DNA vaccine-encoding Toxoplasma gondii microneme protein 11 against acute toxoplasmosis in BALB/c mice. Parasitol Res. 2013 Aug;112(8):2871-7. doi: 10.1007/s00436-013-3458-4. Epub 2013 Jun 10. PubMed PMID: 23749087.